Which of the following factors most likely contributed to the disappearance of the Lost Colony of Roanoke, considering the challenges of English colonization?

The disappearance of the Lost Colony of Roanoke is a mystery that many people have tried to solve. One major factor that likely contributed to their disappearance was the lack of supplies and support from England. When the colonists first arrived, they faced difficulties like harsh weather, unfamiliar land, and limited food. For example, when the supply ship finally returned after three years, it found the colony abandoned, suggesting the settlers may have struggled to survive. Additionally, conflicts with local Native American tribes could have made it even harder for them to thrive in their new environment.