What is one of the major theories explaining the challenges faced by the Lost Colony of Roanoke that may have contributed to its mysterious disappearance?

One major theory about the challenges faced by the Lost Colony of Roanoke is that the settlers struggled with food shortages. When they arrived, they were not fully prepared for the harsh conditions and limited resources of the area. This lack of food likely made it difficult for them to survive, especially if they were unable to establish good relationships with local Native American tribes who could have helped them. For example, if they did not receive enough corn or other food supplies from the nearby tribes, the colonists might have faced starvation. This situation could have led them to leave the colony in search of food or even to abandon it altogether.