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Cyclohexane Chair Conformations
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In a chair conformation of cyclohexane, which statement best explains the implications of substituent positioning on molecular stability?

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A

Equatorial substituents are more stable due to reduced steric hindrance.

B

Axial substituents are always more stable regardless of the size.

C

Substituents can freely rotate between axial and equatorial positions without energy cost.

D

Only bulky substituents affect the stability of chair conformations.

Understanding the Answer

Let's break down why this is correct

When a group sits in an equatorial spot, it is farther from the other atoms in the ring. Other options are incorrect because The belief that axial groups are always better ignores that axial groups touch nearby atoms; Changing a group from axial to equatorial is not a free move.

Key Concepts

Cyclohexane Chair Conformations
Substituent Positioning and Sterics
Molecular Stability
Topic

Cyclohexane Chair Conformations

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medium level question

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Deep Dive: Cyclohexane Chair Conformations

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Definition
Definition

Cyclohexane molecules exhibit chair conformations where axial and equatorial positions determine stability. Chair flips involve interchanging axial and equatorial hydrogens without breaking bonds. The positioning of substituents like methyl groups affects energy levels and steric interactions, impacting molecular stability and reactivity.

Topic Definition

Cyclohexane molecules exhibit chair conformations where axial and equatorial positions determine stability. Chair flips involve interchanging axial and equatorial hydrogens without breaking bonds. The positioning of substituents like methyl groups affects energy levels and steric interactions, impacting molecular stability and reactivity.

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