Practice Questions
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In a substituted cyclohexane with a bulky tert-butyl group and a smaller ethyl group, which configuration minimizes steric hindrance and maximizes stability in the chair conformation?
The tert‑butyl group is large and prefers the equatorial position because it has more space and avoids 1,3‑diaxial interactions. Other options are inc...
When analyzing a cyclohexane derivative with a bulky substituent in the axial position, what effect does ring flipping have on the stability of the molecule?
When the chair flips, the big group moves from the tight axial spot to the open equatorial spot. Other options are incorrect because The misconception...
In a substituted cyclohexane where a large substituent is present in the equatorial position, what is the likely impact on the molecule's stability when the ring undergoes flipping?
When the cyclohexane ring flips, the large substituent moves from the wide equatorial spot to the tight axial spot. Other options are incorrect becaus...
In a cyclohexane derivative featuring both a chlorine atom and a methyl group, which substituent position (axial or equatorial) would likely lead to a more stable chair conformation?
A chlorine atom prefers the equatorial position because it is larger than hydrogen and wants to avoid close contacts with neighboring axial hydrogens....
In a cyclohexane derivative with a bulky substituent in the equatorial position, how does this affect the molecule's overall stability compared to when the same substituent is in the axial position?
When a large group sits in the equatorial spot, it sits lower and spreads out, so the ring has less crowding. Other options are incorrect because Thin...
In a chair conformation of cyclohexane, which statement best explains the implications of substituent positioning on molecular stability?
When a group sits in an equatorial spot, it is farther from the other atoms in the ring. Other options are incorrect because The belief that axial gro...
When considering chair conformations of cyclohexane, which arrangement of substituents generally leads to the most stable conformation?
Equatorial positions keep the substituents farther from the ring's interior. Other options are incorrect because Misconception: All axial would be bes...
Axial positions are to chair conformations as __________ is to molecular stability.
Equatorial positions give substituents less crowding. Other options are incorrect because Linear structures do not change the chair’s strain; Bond ang...
In the chair conformation of cyclohexane, substituents in the ____ position are generally more stable due to reduced steric interactions compared to those in the axial position.
Equatorial positions give a substituent more room. Other options are incorrect because Axial groups are closer to the chair's own hydrogen atoms; Tran...
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