In the context of protein denaturation, the process by which proteins lose their three-dimensional structure and become functionally inactive is known as __________.

The process by which a protein loses its folded shape and stops working is called denaturation. When a protein’s bonds are disrupted—by heat, acid, or chemicals—it unfolds and its active sites are scrambled. Because the three‑dimensional arrangement is essential for function, the protein can no longer bind to other molecules or perform its role. For example, heating a boiled egg turns the clear liquid inside into a solid white, showing how heat denatures the egg’s proteins. This loss of structure is why the protein is no longer functional.