True or False: The integumentary system, while a crucial component of innate immune defenses, is solely responsible for preventing pathogens from entering the body without any assistance from other immune components.

False. The skin and mucous membranes form a physical barrier that stops many microbes from entering, but they are part of a larger network of innate defenses. Cells such as macrophages, neutrophils, and antimicrobial peptides work together with the integumentary system to destroy or neutralize any pathogens that slip through. For example, if a cut allows a bacterium to enter, the skin’s keratinocytes release defensins while nearby immune cells rush to engulf and kill the invader. Thus the integumentary system is essential but not alone in preventing infection.