Arrange the following steps in the process of advancing microbiome research to address future challenges: A) Develop targeted interventions for health modulation, B) Understand host-microbiome interactions, C) Identify specific microbial signatures linked to diseases, D) Utilize advanced sequencing technologies for comprehensive microbiome characterization.

The first step is to use advanced sequencing technologies to comprehensively characterize the microbiome, giving a detailed map of microbial communities. With that map, researchers study host‑microbiome interactions to see how microbes influence and are influenced by the host. Next, scientists look for specific microbial signatures that correlate with particular diseases, turning raw data into meaningful disease markers. Finally, they use those markers to develop targeted interventions that can modulate the microbiome for better health. For example, sequencing a gut sample, mapping its interactions with the host, finding a signature linked to inflammatory bowel disease, and then creating a probiotic treatment to restore balance.