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Alkaline Copper Solution
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What is the primary effect of using an alkaline copper solution in protein analysis?

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Choose the Best Answer

A

It increases the solubility of proteins in water

B

It facilitates the formation of colored complexes with proteins

C

It denatures proteins, making them easier to measure

D

It reduces the absorption of light by proteins in spectrophotometry

Understanding the Answer

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Answer

The alkaline copper solution is used to stain proteins that have been separated by electrophoresis, turning them into dark blue‑black bands on the gel. It works by binding copper ions to the amino groups in the protein, forming a colored complex that is easily visible. Because the copper complex is highly pigmented, faint proteins become detectable, improving the sensitivity of the analysis. For example, after running a gel, dipping it in the solution turns the protein bands dark, allowing you to see and quantify them. This staining step is the primary effect of using the alkaline copper solution in protein analysis.

Detailed Explanation

The copper ions in the alkaline solution bind to protein molecules and create a colored complex. Other options are incorrect because Students often think the solution makes proteins dissolve better; The main goal is not to break the protein structure.

Key Concepts

Protein analysis
Colorimetric detection
Spectrophotometry
Topic

Alkaline Copper Solution

Difficulty

medium level question

Cognitive Level

understand

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