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HomeHomework HelpbiologyPoint mutations

Point mutations

Point mutations are alterations in a single nucleotide base pair in the DNA sequence, which can result in changes to the amino acid sequence of a protein. These mutations can be classified as silent, missense, or nonsense, depending on their effects on protein function.

intermediate
2 hours
Biology
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Overview

Point mutations are small changes in the DNA sequence that can have significant effects on an organism. They can alter the way proteins are made, potentially leading to various traits or diseases. Understanding point mutations is essential for fields like genetics, medicine, and evolutionary biology...

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Key Terms

Nucleotide
The basic building block of DNA and RNA, consisting of a sugar, phosphate group, and nitrogenous base.

Example: A nucleotide can be adenine, thymine, cytosine, or guanine.

Substitution mutation
A type of point mutation where one base is replaced by another.

Example: Changing an A to a G in a DNA sequence.

Insertion mutation
A mutation where one or more nucleotide bases are added to a DNA sequence.

Example: Adding an extra A in a sequence.

Deletion mutation
A mutation where one or more nucleotide bases are removed from a DNA sequence.

Example: Removing a C from a sequence.

Silent mutation
A mutation that does not change the amino acid sequence of a protein.

Example: Changing GAA to GAG, both coding for glutamic acid.

Missense mutation
A mutation that results in a different amino acid being incorporated into a protein.

Example: Changing AAG to GAG, resulting in a change from lysine to glutamic acid.

Related Topics

Genetic disorders
Study of diseases caused by mutations in genes.
intermediate
DNA replication
Understanding how DNA is copied before cell division.
intermediate
Evolutionary biology
Exploring how mutations contribute to the evolution of species.
advanced

Key Concepts

Types of mutationsEffects on proteinsCauses of mutationsRepair mechanisms