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HomeHomework HelpbiologyOncogenes and Tumor Suppressor Genes

Oncogenes and Tumor Suppressor Genes

Oncogenes are mutated forms of normal genes (proto-oncogenes) that promote cell division and survival, potentially leading to cancer when overactive. Tumor suppressor genes are normal genes that regulate cell growth and division, and their loss or inactivation can result in uncontrolled cell proliferation and tumor formation.

intermediate
3 hours
Biology
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Oncogenes and tumor suppressor genes play crucial roles in the regulation of cell growth and division. Oncogenes, when mutated, can lead to uncontrolled cell proliferation, contributing to cancer development. In contrast, tumor suppressor genes act as safeguards, preventing excessive cell division a...

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Key Terms

Oncogene
A gene that has the potential to cause cancer when mutated.

Example: The RAS gene is an oncogene that can lead to uncontrolled cell growth.

Tumor Suppressor Gene
A gene that protects a cell from one step on the path to cancer.

Example: The TP53 gene is a well-known tumor suppressor gene.

Mutation
A change in the DNA sequence of a gene.

Example: Mutations in oncogenes can lead to cancer.

Cell Cycle
The series of events that take place in a cell leading to its division and replication.

Example: The cell cycle includes phases like G1, S, G2, and M.

Apoptosis
The process of programmed cell death.

Example: Tumor suppressor genes can trigger apoptosis in damaged cells.

Carcinogen
A substance capable of causing cancer in living tissue.

Example: Tobacco smoke contains carcinogens that can lead to lung cancer.

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Study of the biological mechanisms that lead to cancer development.
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Examination of the molecular basis of diseases, including cancer.
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Key Concepts

OncogenesTumor Suppressor GenesCell Cycle RegulationCancer Development