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HomeHomework HelpbiologyOkazaki Fragments

Okazaki Fragments

Okazaki fragments are short segments of DNA synthesized discontinuously on the lagging strand during DNA replication, as they are formed in the opposite direction of the replication fork. These fragments are later joined together by the enzyme DNA ligase to create a continuous DNA strand.

intermediate
2 hours
Biology
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Overview

Okazaki fragments are crucial components of DNA replication, specifically on the lagging strand. They are short segments of DNA that are synthesized discontinuously due to the directionality of DNA polymerase, which can only add nucleotides in the 5' to 3' direction. Understanding Okazaki fragments ...

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Key Terms

DNA replication
The process of copying a DNA molecule to produce two identical DNA molecules.

Example: DNA replication occurs before cell division.

Lagging strand
The DNA strand that is synthesized discontinuously in short segments.

Example: The lagging strand is made up of Okazaki fragments.

Leading strand
The DNA strand that is synthesized continuously in the same direction as the replication fork.

Example: The leading strand is synthesized without interruption.

Okazaki fragments
Short segments of DNA synthesized on the lagging strand during DNA replication.

Example: Okazaki fragments are later joined by DNA ligase.

DNA polymerase
An enzyme that synthesizes new DNA strands by adding nucleotides.

Example: DNA polymerase is essential for DNA replication.

DNA ligase
An enzyme that joins Okazaki fragments together to form a continuous DNA strand.

Example: DNA ligase seals the gaps between fragments.

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Key Concepts

DNA replicationlagging strandOkazaki fragmentsDNA polymerase