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HomeHomework HelpbiologyEpigenetics Overview

Epigenetics Overview

Epigenetics refers to the study of heritable changes in gene expression that do not involve alterations to the underlying DNA sequence, primarily through mechanisms such as DNA methylation and histone modification. DNA methylation involves the addition of a methyl group to DNA, typically suppressing gene activity, while histone modification involves chemical changes to the proteins around which DNA is wrapped, influencing chromatin structure and gene accessibility.

intermediate
3 hours
Biology
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Overview

Epigenetics is a fascinating field that explores how gene expression is regulated without changes to the DNA sequence itself. It involves mechanisms like DNA methylation and histone modification, which can turn genes on or off, influencing everything from development to disease. Understanding epigen...

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Key Terms

Epigenetics
The study of heritable changes in gene expression that do not involve changes to the DNA sequence.

Example: Epigenetics explains how identical twins can have different traits.

DNA Methylation
The addition of a methyl group to DNA, often leading to gene silencing.

Example: In cancer cells, abnormal DNA methylation patterns can silence tumor suppressor genes.

Histone
Proteins around which DNA is wrapped, playing a key role in gene regulation.

Example: Histones can be modified to either tighten or loosen DNA, affecting gene accessibility.

Chromatin
The complex of DNA and proteins that forms chromosomes within the nucleus.

Example: Chromatin structure can change based on histone modifications.

Gene Expression
The process by which information from a gene is used to synthesize functional gene products like proteins.

Example: Gene expression can be upregulated or downregulated by epigenetic mechanisms.

Transcription
The process of copying a segment of DNA into RNA.

Example: Transcription is the first step in gene expression.

Related Topics

Genomics
The study of genomes, the complete set of DNA within an organism, including its structure, function, evolution, and mapping.
intermediate
Molecular Biology
The branch of biology that deals with the molecular basis of biological activity, including interactions between DNA, RNA, and proteins.
intermediate
Cancer Biology
The study of cancer, focusing on the cellular and molecular mechanisms that lead to cancer development and progression.
advanced

Key Concepts

DNA MethylationHistone ModificationGene ExpressionEnvironmental Influence