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HomeHomework HelpbiologyDNA Repair Mechanisms

DNA Repair Mechanisms

The processes by which cells maintain the integrity of their genetic material, including the repair of DNA damage caused by heat, UV radiation, chemicals, and free radicals, through various mechanisms such as depurination, deamination, and mismatch repair

intermediate
3 hours
Biology
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Overview

DNA repair mechanisms are vital for maintaining the integrity of genetic information within cells. They protect against various types of DNA damage caused by environmental factors, replication errors, and other sources. Understanding these mechanisms is crucial for comprehending how cells prevent mu...

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Key Terms

DNA
Deoxyribonucleic acid, the molecule that carries genetic information.

Example: DNA is found in the nucleus of cells.

Mutation
A change in the DNA sequence that can lead to altered gene function.

Example: Some mutations can cause diseases.

Base Excision Repair
A DNA repair pathway that removes and replaces damaged bases.

Example: Base excision repair fixes small, non-helix-distorting base lesions.

Nucleotide Excision Repair
A repair mechanism that removes bulky DNA adducts and replaces them.

Example: Nucleotide excision repair is crucial for fixing UV-induced damage.

DNA Ligase
An enzyme that joins DNA fragments together.

Example: DNA ligase is essential for sealing nicks in the DNA backbone.

DNA Polymerase
An enzyme responsible for synthesizing new DNA strands.

Example: DNA polymerase adds nucleotides to a growing DNA strand.

Related Topics

Cell Cycle Regulation
Understanding how the cell cycle is controlled and its relation to DNA repair mechanisms.
intermediate
Cancer Biology
Exploring the relationship between DNA repair defects and cancer development.
advanced
Genetic Engineering
Learning about techniques that manipulate DNA, including repair mechanisms.
intermediate

Key Concepts

Types of DNA damageRepair pathwaysEnzymatic rolesSignificance of repair